学习和工作经历

1973.09-1976.09, 山西医学院(现山西医科大学), 获学士学位

1979.09-1982.04, 中国医学科学院, 获硕士学位

1985.01-1986.08, 美国马里兰大学, 访问学者

1986.08-1987.10, 美国佐治亚大学, 访问学者

1987.10-1989.08, 中国预防医学科学院流行病学微生物学研究所, 助理研究员

1989.08-1993.08, 中国预防医学科学院, 获博士学位(其间于1991.06-1993.08在美国马里兰大学做访问学者)

1995-2002, 中国预防医学科学院流行病学微生物学研究所, 历任副所长、所长 

2002-2014, 中国疾病预防控制中心传染病预防控制所, 所长

1996-2005, 卫生部分子医学细菌学重点实验室, 主任

2005-至今, 传染病预防控制国家重点实验室, 主任 

2020.05-至今, 滚球体育曼城 公共卫生与健康研究院, 院长


学术与社会任职

1.“艾滋病和传染性肝炎等重大传染病防治”科技重大专项, 技术副总师、能力建设领域专家组组长

2.第二届国家病原微生物实验室生物安全专家委员会, 主任委员

3.中国合格评定国家认可委员会(CNAS)第三届实验室技术委员会生物安全专业委员会, 主任委员

4.国务院食品安全委员会第一届专家委员会, 委员

5.中华医学会, 常务理事

6.中国微生物学会, 副理事长

7.中国有害生物防制协会, 会长

8.第二届全国动物防疫专家委员会, 委员

9.全球微生物识别Global Microbial Identifier, 常务理事

10.中国工程院医药卫生学部, 副主任

11.中国医学科学院卫生健康与环境医学学部, 主任委员

12.Emerging Microbial Infection,  Associate Editor

13.Frontier of Medicine,  Member of editorial Board

14.《微生物学报》, 副主编

15.《中国人兽共患病学报》, 副主编

16.《疾病监测》, 主编

17.《首都公共卫生杂志》, 主编

18.《中国公共卫生杂志》, 主编


研究方向

1.新病原发现

2.人体细菌学

3.反向病原学研究


主持科研项目

1.新型冠状病毒等野生动物源新发传染病防控策略, 中国工程院咨询项目, 2020.04-2020.09.

2.动物源性病原体及其对人致病性, 国家自然科学基金委重大项目, 2013-2017.

3.我国未来传染病和发现新病原战略研究,中国工程院和国家自然科学基金委联合资助重大咨询项目, 2016-2017.

4.新型国家预防医学体系建立研究报告, 中国工程院重大咨询课题“全民健康与医药卫生事业国家发展战略研究” 课题三, 2014-2016.

5.医药卫生领域课题, 中国工程院“中国工程科技2035发展战略研究”, 2015-2017.

6.我国公共卫生人才培养战略研究, 中国工程院重大咨询项目 “我国医药卫生人才培养战略研究”子课题, 2016-2018.


代表性论文与专利

长期从事新发、突发、不明原因性传染病疫情的病原学研究,主持完成9起在我国有较大影响的传染病疫情或事件的病原学调查,在我国发现2种新发传染病(大肠杆菌O157: H7感染、人粒细胞无形体病),发现6种新的发生变异的具有重要公共卫生意义的病原体(脑膜炎奈瑟氏菌4821序列群、序列7型猪链球菌、福氏志贺氏菌Xv血清型、大肠杆菌O157: H7 序列型96、产毒性集聚性粘附弗氏枸橼酸菌、巴黎链球菌等)。所取得的科研成果,提高了传染病疫情应急处置的科技水平和控制效果,至今为止发表SCI论文200余篇,包括JAMALancetNatureClinical Infectious DiseaseEmerging Infectious Diseases等著名期刊。

1. Xiaoyi Dai, Guobao Shang, Shan Lu, Jing Yang, Jianguo Xu*. A new subtype of eastern tick-borne encephalitis virus discovered in Qinghai-Tibet Plateau, China. Emerging Microbes & Infections, 2018, 7.

2. Pengcheng Du, Han Zheng, Jieping Zhou, Ruiting Lan, Changyun Ye, Huaiqi Jing, Dong Jin, Zhigang Cui, Xuemei Bai, Jianming Liang, Jiantao Liu, Lei Xu, Wen Zhang, Chen Chen, Jianguo Xu*. Detection of multiple parallel transmission outbreak of streptococcus suis human infection by use of genome epidemiology, China, 2005. Emerging Infectious Diseases, 2017, 23(2): 204-211.

3. Wenping Guo*, Xiandan Lin, Wen Wang, Junhua Tian, Meili Cong, Hailin Zhang, Miaoruo Wang, Runhong Zhou, Jianbo Wang, Minghui Li, Jianguo Xu, Edward C. Holmes, Yongzhen Zhang. Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. Plos Pathogens, 2013, 9(2).

4. Cixiu Li, Mang Shi, Junhua Tian, Xiandan Lin, Yanjun Kang, Liangjun Chen, Xincheng Qin, Jianguo Xu, Edward C. Holmes, Yongzhen Zhang*. Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses. Elife, 2015, 4.

5. Qiyong Liu, Wenbo Xu, Shan Lu, Jiafu Jiang, Jieping Zhou, Zhujun Shao, Xiaobo Liu, Lei Xu, Yanwen Xiong, Han Zheng, Sun Jin, Hai Jiang, Wuchun Cao, Jianguo Xu*. Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior. Frontiers of Medicine, 2018, 12(1): 3-22.

6. Shan Lu, Dong Jin, Shusheng Wu, Jing Yang, Ruiting Lan, Xiangning Bai, Sha Liu, Qiong Meng, Xuejiao Yuan, Juan Zhou, Ji Pu, Qiang Chen, Hang Dai, Yuanyuan Hu, Yanwen Xiong, Changyun Ye, Jianguo Xu*. Insights into the evolution of pathogenicity of Escherichia coli from genomic analysis of intestinal E-coli of Marmota himalayana in Qinghai-Tibet plateau of China. Emerging Microbes & Infections, 2016, 5.

7. Xuelian Luo, Shan Lu, Dong Jin, Jing Yang, Shu-sheng Wu, Jianguo Xu*. Marmota himalayana in the Qinghai-Tibetan plateau as a special host for bi-segmented and unsegmented picobirnaviruses. Emerging Microbes & Infections, 2018, 7.

8. Xiangli Meng, Shan Lu, Jing Yang, Dong Jin, Xiaohong Wang, Xiangning Bai, Yumeng Wen, Yiting Wang, Lina Niu, Changyun Ye, Ramon Rossello-Mora, Jianguo Xu*. Metataxonomics reveal vultures as a reservoir for Clostridium perfringens. Emerging Microbes & Infections, 2017, 6.

9. Xincheng Qin, Mang Shi, Junhua Tian, Xiandan Lin, Dongya Gao, Jinrong He, Jianbo Wang, Cixiu Li, Yanjun Kang, Bin Yu, Dunjin Zhou, Jianguo Xu, Alexander Plyusnin, Edward C. Holmes, Yongzhen Zhang*. A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors[J]. Proceedings of The National Academy of Sciences of The United States of America, 2014, 111(18): 6744-6749.

10. S. X. Ren, F. Gang, X. G. Jiang, R. Zeng, Y. G. Miao, H. Xu, Y. X. Zhang, H. Xiong, G. Lu, L. F. Lu, H. Q. Jiang, J. Jia, Y. F. Tu, J. X. Jiang, W. Y. Gu, Y. Q. Zhang, Z. Cai, H. H. Sheng, H. F. Yin, Y. Zhang, G. F. Zhu, M. Wan, H. L. Huang, Z. Qian, S. Y. Wang, W. Ma, Z. J. Yao, Y. Shen, B. Q. Qiang, Q. C. Xia, X. K. Guo, A. Danchin, I. Saint Girons, R. L. Somerville, Y. M. Wen, M. H. Shi, Z. Chen, J. G. Xu, G. P. Zhao*. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature, 2003, 422(6934): 888-893.

11. Holger Rohde, Junjie Qin, Yujun Cui, Dongfang Li, Nicholas J. Loman, Moritz Hentschke, Wentong Chen, Fei Pu, Yangqing Peng, Junhua Li, Feng Xi, Shenghui Li, Yin Li, Zhaoxi Zhang, Xianwei Yang, Meiru Zhao, Peng Wang, Yuanlin Guan, Zhong Cen, Xiangna Zhao, Martin Christner, Robin Kobbe, Sebastian Loos, Jun Oh, Liang Yang, Antoine Danchin, George F. Gao, Yajun Song, Yingrui Li, Huanming Yang, Jian Wang, Jianguo Xu, Mark J. Pallen*, Jun Wang, Martin Aepfelbacher, Ruifu Yang. Open-Source genomic analysis of shiga-toxin–producing E. coli O104: H4. New England Journal of Medicine, 2011, 365(8): 718-724.

12. Z. J. Shao, W. Li, J. Ren, X. F. Liang, L. Xu, B. W. Diao, M. C. Li, M. J. Lu, H. Y. Ren, Z. G. Cui, B. Q. Zhu, Z. W. Dai, L. Zhang, X. Chen, B. Kan, J. G. Xu*. Identification of a new Neisseria meningitidis serogroup C clone from Anhui province, China. Lancet, 2006, 367(9508): 419-423.

13. Mang Shi, Xiandan Lin, Junhua Tian, Liangjun Chen, Xiao Chen, Cixiu Li, Xincheng Qin, Jun Li, Jianping Cao, John Sebastian Eden, Jan Buchmann, Wen Wang, Jianguo Xu, Edward C. Holmes, Yongzhen Zhang*. Redefining the invertebrate RNA virosphere. Nature, 2016, 540(7634): 539.

14. Mang Shi, Xiandan Lin, Nikos Vasilakis, Junhua Tian, Cixiu Li, Liangjun Chen, Gillian Eastwood, Xiunian Diao, Minghui Chen, Xiao Chen, Xincheng Qin, Steven G. Widen, Thomas G. Wood, Robert B. Tesh, Jianguo Xu, Edward C. Holmes, Yongzhen Zhang*. Divergent viruses discovered in arthropods and vertebrates revise the evolutionary history of the flaviviridae and related viruses. Journal of Virology, 2016, 90(2): 659-669.

15. Qiangzheng Sun*, Yuriy A. Knirel, Jianping Wang, Xia Luo, Sofya N. Senchenkova, Ruiting Lan, Alexander S. Shashkov, Jianguo Xu. Serotype-Converting bacteriophage SfII encodes an acyltransferase protein that mediates 6-O-Acetylation of GlcNAc in shigella flexneri O-Antigens, conferring on the host a novel O-Antigen epitope. Journal of Bacteriology, 2014, 196(20): 3656-3666.

16. Jianguo Xu*. Reverse microbial etiology: A research field for predicting and preventing emerging infectious diseases caused by an unknown microorganism. Journal of biosafety and biosecurity, 2019, 1(1): 19-21.

17. Jianguo Xu*, Shan Lu, Haiyin Wang, Chen Chen. Reducing exposure to avian influenza H7N9. Lancet, 2013, 381(9880): 1815-1816.

18. Lei Xu, Leif C. Stige, Kung Sik Chan, Jie Zhou, Jun Yang, Shaowei Sang, Ming Wang, Zhicong Yang, Ziqiang Yan, Tong Jiang, Liang Lu, Yujuan Yue, Xiaobo Liu, Hualiang Lin, Jianguo Xu*, Qiyong Liu*, Nils Chr Stenseth. Climate variation drives dengue dynamics. Proceedings of The National Academy of Sciences of The United States of America, 2017, 114(1): 113-118.

19. Changyun Ye, Xuemei Bai, Ji Zhang, Huaiqi Jing, Han Zheng, Huamao Du, Zhigang Cui, Shouying Zhang, Dong Jin, Yanmei Xu, Yanwen Xiong, Ailan Zhao, Xia Luo, Qiangzheng Sun, Marcelo Gottschalk, Jianguo Xu*. Spread of streptococcus suis sequence type 7, China. Emerging Infectious Diseases, 2008, 14(5): 787-791.

20. Changyun Ye, Han Zheng, Ji Zhang, Huaiqi Jing, Lei Wang, Yanwen Xiong, Wei Wang, Zhemin Zhou, Qiangzheng Sun, Xia Luo, Huamao Du, Marcelo Gottschalk, Jianguo Xu*. Clinical, Experimental, and Genomic Differences between Intermediately Pathogenic, Highly Pathogenic, and Epidemic Streptococcus suis. Journal of Infectious Diseases, 2009, 199(1): 97-107.

21. Changyun Ye, Xiaoping Zhu, Huaiqi Jing, Huamao Du, Mariela Segura, Han Zheng, Biao Kan, Lili Wang, Xuemei Bai, Yongyun Zhou, Zhigang Cui, Shouying Zhang, Dong Jin, Na Sun, Xia Luo, Ji Zhang, Zhaolong Gong, Xin Wang, Lei Wang, Hui Sun, Zhenjun Li, Qiangzheng Sun, Honglu Liu, Boqing Dong, Changwen Ke, Hui Yuan, Hua Wang, Kecheng Tian, Yu Wang, Marcelo Gottschalk, Jianguo Xu*. Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerging Infectious Diseases, 2006, 12(8): 1203-1208.

22. Hongjie Yu, Huaiqi Jing, Zhihai Chen, Han Zheng, Xiaoping Zhu, Hua Wang, Shiwen Wang, Lunguang Liu, Rongqiang Zu, Longze Luo, Nijuan Xiang, Honglu Liu, Xuecheng Liu, Yuellong Shu, Shui Shan Lee, Shuk Kwan Chuang, Yu Wang, Jianguo Xu, Weizhong Yang*, Grp Streptococcus suis Study. Human Streptococcus suis outbreak, Sichuan, China. Emerging Infectious Diseases, 2006, 12(6): 914-920.

23. Jiemei Yu, Lili Li, Cuiyuan Zhang, Shan Lu, Yuanyun Ao, Hanchun Gao, Zhiping Xie, Guangcheng Xie, Xiaoman Sun, Lili Pang, Jianguo Xu, W. Ian Lipkin, Zhaojun Duan*. A novel hepatovirus identified in wild woodchuck Marmota himalayana. Scientific Reports, 2016, 6.

24. Lijuan Zhang, Yan Liu, Daxin Ni, Qun Li, Yanlin Yu, Xuejie Yu, Kanglin Wan, Dexin Li, Guodong Liang, Xiugao Jiang, Huaiqi Jing, Jing Run, Mingchun Luan, Xiuping Fu, Jingshan Zhang, Weizhong Yang, Yu Wang, J. Stephen Dumler, Zijian Feng, Jun Ren, Jianguo Xu*. Nosocomial Transmission of Human Granulocytic Anaplasmosis in China. Jama-journal of The American Medical Association, 2008, 300(19): 2263-2270.

25. Nan Zhang, Ruiting Lan, Qiangzheng Sun, Jianping Wang, Yiting Wang, Jin Zhang, Deshan Yu, Wanfu Hu, Shoukui Hu, Hang Dai, Pengcheng Du, Haiyin Wang, Jianguo Xu*. Genomic Portrait of the Evolution and Epidemic Spread of a Recently Emerged Multidrug-Resistant Shigella flexneri Clone in China. Journal of Clinical Microbiology, 2014, 52(4): 1119-1126.

26. Yongzhen Zhang, Yongwen He, Yongan Dai, Yanwen Xiong, Han Zheng, Dunjin Zhou, Juan Li, Qiangzheng Sun, Xuelian Luo, Yuli Cheng, Xincheng Qin, Junhua Tian, Xiaoping Chen, Bin Yu, Dong Jin, Wenping Guo, Wei Li, Wen Wang, Jinsong Peng, Guobin Zhang, Shaomin Zhang, Xiaomin Chen, Yan Wang, Minghui Li, Zhenjun Li, Shan Lu, Changyun Ye, Menno D. de Jong, Jianguo Xu*. Hemorrhagic Fever Caused by a Novel Bunyavirus in China: Pathogenesis and Correlates of Fatal Outcome. Clinical Infectious Diseases, 2012, 54(4): 527-533.

27. Yongzhen Zhang, Jianguo Xu*. The emergence and cross species transmission of newly discovered tick-borne Bunyavirus in China. Current Opinion in Virology, 2016, 16: 126-131.

28. Yongzhen Zhang, Dunjin Zhou, Xincheng Qin, Junhua Tian, Yanwen Xiong, Jianbo Wang, Xiaoping Chen, Dongya Gao, Yongwen He, Dong Jin, Qiangzheng Sun, Wenping Guo, Wen Wang, Bin Yu, Juan Li, Yongan Dai, Wei Li, Jinsong Peng, Guobin Zhang, Shaomin Zhang, Xiao-Min Chen, Yan Wang, Minghui Li, Xin Lu, Changyun Ye, Menno D. de Jong, Jianguo Xu*. The Ecology, Genetic Diversity, and Phylogeny of Huaiyangshan Virus in China. Journal of Virology, 2012, 86(5): 2864-2868.

29. Yongzhen Zhang, Dunjin Zhou, Yanwen Xiong, Xiaoping Chen, Yongwen He, Qiangzheng Sun, Bin Yu, Juan Li, Yongan Dai, Junhua Tian, Xincheng Qin, Dong Jin, Zhigang Cui, Xuelian Luo, Wei Li, Shan Lu, Wen Wang, Jinsong Peng, Wenping Guo, Minghui Li, Zhenjun Li, Shaomin Zhang, Chen Chen, Yan Wang, Menno D. de Jong, Jianguo Xu*. Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua liu xing bing xue za zhi, 2011, 32(3): 209-220.


荣誉和奖励

1995, 人力资源和社会保障部, 优秀留学回国人员

1996, 卫生部, 第二届百名医学青年科技之星

1996, 国务院, 享受国务院政府特殊津贴

1997, 国务院, 国家科技进步奖二等奖(排名第1)

1998, 人力资源和社会保障部, 有突出贡献的中青年专家

2001, 中国科学技术协会, 全国优秀科技工作者

2001, 何梁何利基金委员会, 何梁何利医药进步奖

2009, 卫生部, 卫生应急先进个人

2013, 北京市政府, 北京市有突出贡献的科学技术管理人才

2019, 国家卫建委, 中国好医生中国好护士-2019年度人物


联系方式

通讯地址:天津市海河教育园同砚路38号 300350

电子邮件:xujianguo@icdc.cn